翻訳と辞書 Words near each other ・ Succinea sanctaehelenae ・ Succinea tenella ・ Succineidae ・ Succinella ・ Succinella oblonga ・ Succinic acid ・ Succinic acid fermentation ・ Succinic anhydride ・ Succinic semialdehyde ・ Succinic semialdehyde dehydrogenase deficiency ・ Succinimide ・ Succinipatopsis ・ Succinivibrionaceae ・ Succinodon ・ Succinonitrile ・ Succinyl coenzyme A synthetase ・ Succinyl-CoA ・ Succinyl-CoA hydrolase ・ Succinyl-diaminopimelate desuccinylase ・ Succinylation ・ Succinyldiaminopimelate transaminase ・ Succinylglutamate desuccinylase ・ Succinylglutamate-semialdehyde dehydrogenase ・ Succinylmonocholine ・ Succinylornithine aminotransferase ・ Succinylornithine transaminase ・ Succinylsulfathiazole ・ Succisa ・ Succisa pentaphylla ・ Succisa pratensis Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Succinyl coenzyme A synthetase ： ウィキペディア英語版 Succinyl coenzyme A synthetase Succinyl coenzyme A synthetase (SCS, also known as succinyl-CoA synthetase or succinate thiokinase or succinate-CoA ligase) is an enzyme that catalyzes the reversible reaction of succinyl-CoA to succinate. The enzyme facilitates the coupling of this reaction to the formation of a nucleoside triphosphate molecule (either GTP or ATP) from an inorganic phosphate molecule and a nucleoside diphosphate molecule (either GDP or ADP). It plays a key role as one of the catalysts involved in the citric acid cycle, a central pathway in cellular metabolism, and it is located within the mitochondrial matrix of a cell. ==Chemical Reaction and Enzyme Mechanism== Succinyl CoA synthetase catalyzes the following reversible reaction: :Succinyl CoA + Pi + NDP ↔ Succinate + CoA + NTP where Pi denotes inorganic phosphate, NDP denotes nucleoside diphosphate (either GDP or ADP), and NTP denotes nucleoside triphosphate (either GTP or ATP). As mentioned, the enzyme facilitates coupling of the conversion of succinyl CoA to succinate with the formation of NTP from NDP and Pi. The reaction has a biochemical standard state free energy change of -3.4 kJ/mol.〔 The reaction takes place by a three-step mechanism〔 which is depicted in the image below. The first step involves displacement of CoA from succinyl CoA by a nucleophilic inorganic phosphate molecule to form succinyl phosphate. The enzyme then utilizes a histidine residue to remove the phosphate group from succinyl phosphate and generate succinate. Finally, the phosphorylated histidine transfers the phosphate group to a nucleoside diphosphate, which generates the high-energy carrying nucleoside triphosphate. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Succinyl coenzyme A synthetase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.